Pub. Date : 2020 Dec
PMID : 33025742
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Consistently, TRAP1 enhances GLUT1 expression, glucose uptake and lactate production and downregulates OXPHOS in CRC patient-derived spheroids and cell lines. | Lactic Acid | TNF receptor associated protein 1 | Homo sapiens |
2 | Mechanistically, TRAP1 maximizes lactate production to balance low OXPHOS through the regulation of the glycolytic enzyme phosphofructokinase-1 (PFK1); this depends on the interaction between TRAP1 and PFK1, which favors PFK1 glycolytic activity and prevents its ubiquitination/degradation. | Lactic Acid | TNF receptor associated protein 1 | Homo sapiens |
3 | By contrast, TRAP1/PFK1 interaction is lost in conditions of enhanced OXPHOS, which results in loss of TRAP1 regulation of PFK1 activity and lactate production. | Lactic Acid | TNF receptor associated protein 1 | Homo sapiens |
4 | By contrast, TRAP1/PFK1 interaction is lost in conditions of enhanced OXPHOS, which results in loss of TRAP1 regulation of PFK1 activity and lactate production. | Lactic Acid | TNF receptor associated protein 1 | Homo sapiens |