Title : TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.

Pub. Date : 2020 Dec

PMID : 33025742






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Consistently, TRAP1 enhances GLUT1 expression, glucose uptake and lactate production and downregulates OXPHOS in CRC patient-derived spheroids and cell lines. Lactic Acid TNF receptor associated protein 1 Homo sapiens
2 Mechanistically, TRAP1 maximizes lactate production to balance low OXPHOS through the regulation of the glycolytic enzyme phosphofructokinase-1 (PFK1); this depends on the interaction between TRAP1 and PFK1, which favors PFK1 glycolytic activity and prevents its ubiquitination/degradation. Lactic Acid TNF receptor associated protein 1 Homo sapiens
3 By contrast, TRAP1/PFK1 interaction is lost in conditions of enhanced OXPHOS, which results in loss of TRAP1 regulation of PFK1 activity and lactate production. Lactic Acid TNF receptor associated protein 1 Homo sapiens
4 By contrast, TRAP1/PFK1 interaction is lost in conditions of enhanced OXPHOS, which results in loss of TRAP1 regulation of PFK1 activity and lactate production. Lactic Acid TNF receptor associated protein 1 Homo sapiens