Title : Evaluation of the potential role of long non-coding RNA LINC00961 in luminal breast cancer: a case-control and systems biology study.

Pub. Date : 2020

PMID : 33024416






6 Functional Relationships(s)
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1 The purpose of the present study was to investigate the possible role of LINC00961 in luminal A and B subtypes of BC. Phenobarbital small regulatory polypeptide of amino acid response Homo sapiens
2 After performing literature review, the expression level of the selected lncRNA (LINC00961) was evaluated in 79 luminal A and B BC specimens and adjacent non-cancerous tissues by Quantitative Reverse Transcription PCR (qRT-PCR). Phenobarbital small regulatory polypeptide of amino acid response Homo sapiens
3 According to q-RT PCR assay, LINC00961 was downregulated in luminal BC tissues and cell lines. Phenobarbital small regulatory polypeptide of amino acid response Homo sapiens
4 The final results indicated that LINC00961 might be involved in multiple cancer-associated pathways such as chemokine, Ras and PI3K-Akt signaling pathways, GPCR ligand binding, and signal transduction in luminal subtypes of BC. Phenobarbital small regulatory polypeptide of amino acid response Homo sapiens
5 Conclusion: Our findings suggested that LINC00961 was significantly downregulated in luminal A and B subtypes of BC. Phenobarbital small regulatory polypeptide of amino acid response Homo sapiens
6 Moreover, bioinformatics analysis provided a basis for better identification of the potential role of LINC00961 in luminal subtype of BC. Phenobarbital small regulatory polypeptide of amino acid response Homo sapiens