Title : Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.

Pub. Date : 2020 Oct 6

PMID : 33023985






1 Functional Relationships(s)
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1 The decrease in SDH levels in tumor cells resulted in an accumulation of succinate, which enhanced the stability of the transcription factor HIF1alpha and reprogrammed cell metabolism to a glycolytic state. Succinic Acid aminoadipate-semialdehyde synthase Mus musculus