Title : Functional benefits of corticosteroid and IVIG combination therapy in a coronary artery endothelial cell model of Kawasaki disease.

Pub. Date : 2020 Oct 6

PMID : 33023630






3 Functional Relationships(s)
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1 RESULTS: DEX, but not IgG, significantly inhibited apoptosis caused by inflammatory stimuli, resulting in effective reduction of HMGB1 and IL-1alpha protein release by HCAECs. Dexamethasone interleukin 1 alpha Homo sapiens
2 As previously reported, DEX or IgG alone significantly suppressed TNF-alpha-induced production of IL-6 and G-CSF and mRNA expression, but induction of those cytokines by IL-1 s (IL-1alpha and IL-1beta) was resistant to high-dose IgG. Dexamethasone interleukin 1 alpha Homo sapiens
3 As previously reported, DEX or IgG alone significantly suppressed TNF-alpha-induced production of IL-6 and G-CSF and mRNA expression, but induction of those cytokines by IL-1 s (IL-1alpha and IL-1beta) was resistant to high-dose IgG. Dexamethasone interleukin 1 alpha Homo sapiens