Pub. Date : 2020 Oct 1
PMID : 33019717
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Specific c-Jun N-Terminal Kinase Inhibitor, JNK-IN-8 Suppresses Mesenchymal Profile of PTX-Resistant MCF-7 Cells through Modulating PI3K/Akt, MAPK and Wnt Signaling Pathways. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | According to the significant SAPK/JNK activation in PTX-res MCF-7 cells, specific c-Jun N-terminal kinase inhibitor, JNK-IN-8 is shown to suppress the migration potential of cells. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | However, the JNK inhibitor further downregulated Wnt signaling members in PTX-res MCF-7 cells. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Therefore, the JNK inhibitor JNK-IN-8 might be used as a potential therapy model to reverse PTX-resistance related to Wnt signaling. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |
| 5 | Therefore, the JNK inhibitor JNK-IN-8 might be used as a potential therapy model to reverse PTX-resistance related to Wnt signaling. | Paclitaxel | mitogen-activated protein kinase 8 | Homo sapiens |