Title : Insulin as a growth factor in rat hepatoma cells. Stimulation of proto-oncogene expression.

Pub. Date : 1987 Aug 5

PMID : 3301843






3 Functional Relationships(s)
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1 The phorbol ester phorbol 12-myristate 13-acetate (PMA) also induces c-myc and c-fos mRNAs without inducing DNA synthesis. Tetradecanoylphorbol Acetate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 The phorbol ester phorbol 12-myristate 13-acetate (PMA) also induces c-myc and c-fos mRNAs without inducing DNA synthesis. Tetradecanoylphorbol Acetate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
3 However, the mechanism of this induction appears to be different from the insulin-induced induction since pretreatment of cells with PMA blocks only the PMA-mediated, not the insulin-mediated, induction of c-myc and c-fos. Tetradecanoylphorbol Acetate Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus