Title : Caffeine Targets SIRT3 to Enhance SOD2 Activity in Mitochondria.

Pub. Date : 2020

PMID : 33015038






1 Functional Relationships(s)
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1 Mechanistically, caffeine bound to SIRT3 with high affinity (K D = 6.858 x 10-7 M); the binding affinity between SIRT3 and its substrate acetylated p53 was also 9.03 (without NAD+) or 6.87 (with NAD+) times higher in the presence of caffeine. Caffeine tumor protein p53 Homo sapiens