Title : Genetic Variation in the Androgen Receptor Modifies the Association Between Testosterone and Vitality in Middle-Aged Men.

Pub. Date : 2020 Dec

PMID : 33011098






12 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Genetic Variation in the Androgen Receptor Modifies the Association Between Testosterone and Vitality in Middle-Aged Men. Testosterone androgen receptor Homo sapiens
2 AIM: The aim of the present study was to determine if the relationship between circulating testosterone levels and vitality would be moderated by the CAG repeat length in the androgen receptor (AR) gene, which influences the receptor"s sensitivity to testosterone. Testosterone androgen receptor Homo sapiens
3 AIM: The aim of the present study was to determine if the relationship between circulating testosterone levels and vitality would be moderated by the CAG repeat length in the androgen receptor (AR) gene, which influences the receptor"s sensitivity to testosterone. Testosterone androgen receptor Homo sapiens
4 AIM: The aim of the present study was to determine if the relationship between circulating testosterone levels and vitality would be moderated by the CAG repeat length in the androgen receptor (AR) gene, which influences the receptor"s sensitivity to testosterone. Testosterone androgen receptor Homo sapiens
5 AIM: The aim of the present study was to determine if the relationship between circulating testosterone levels and vitality would be moderated by the CAG repeat length in the androgen receptor (AR) gene, which influences the receptor"s sensitivity to testosterone. Testosterone androgen receptor Homo sapiens
6 RESULTS: We observed a significant interaction between salivary testosterone and the AR-CAG repeat length. Testosterone androgen receptor Homo sapiens
7 CLINICAL TRANSLATION: The observed interaction between testosterone and variation in the AR gene suggests that men with more sensitive ARs, as indicated by a shorter AR-CAG repeat, are more likely to experience symptoms of age-related testosterone deficiency. Testosterone androgen receptor Homo sapiens
8 CLINICAL TRANSLATION: The observed interaction between testosterone and variation in the AR gene suggests that men with more sensitive ARs, as indicated by a shorter AR-CAG repeat, are more likely to experience symptoms of age-related testosterone deficiency. Testosterone androgen receptor Homo sapiens
9 CLINICAL TRANSLATION: The observed interaction between testosterone and variation in the AR gene suggests that men with more sensitive ARs, as indicated by a shorter AR-CAG repeat, are more likely to experience symptoms of age-related testosterone deficiency. Testosterone androgen receptor Homo sapiens
10 CLINICAL TRANSLATION: The observed interaction between testosterone and variation in the AR gene suggests that men with more sensitive ARs, as indicated by a shorter AR-CAG repeat, are more likely to experience symptoms of age-related testosterone deficiency. Testosterone androgen receptor Homo sapiens
11 CONCLUSIONS: The association between testosterone and vitality appears to be clinically meaningful and is in part dependent on variation in the AR gene. Testosterone androgen receptor Homo sapiens
12 Genetic Variation in the Androgen Receptor Modifies the Association Between Testosterone and Vitality in Middle-Aged Men. Testosterone androgen receptor Homo sapiens