Title : SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate.

Pub. Date : 2020 Oct 2

PMID : 33009401






3 Functional Relationships(s)
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1 SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens
2 Further, we uncover that NRF2 agonists 4-octyl-itaconate (4-OI) and the clinically approved dimethyl fumarate (DMF) induce a cellular antiviral program that potently inhibits replication of SARS-CoV2 across cell lines. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens
3 In conclusion, NRF2 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective in limiting virus replication and in suppressing the pro-inflammatory responses of human pathogenic viruses, including SARS-CoV2. Dimethyl Fumarate NFE2 like bZIP transcription factor 2 Homo sapiens