Pub. Date : 2020 Sep 30
PMID : 33008033
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Furthermore, simvastatin 40 mg/kg most profoundly attenuated tubular apoptosis, determined as a decrease of cytochrome C, caspase-3 expression, and AIs (p < 0.01 vs. LPS). | Simvastatin | caspase 3 | Homo sapiens |
2 | Conversely, simvastatin induced a significant increase of Bcl-XL and survivin, both in the strong inverse correlations with cleaved caspase-3 and cytochrome C. | Simvastatin | caspase 3 | Homo sapiens |
3 | Our study indicates that simvastatin has cytoprotective effects against LPS-induced tubular apoptosis, seemingly mediated by upregulation of cell-survival molecules, such as Bcl-XL and survivin, and inhibition of the mitochondrial cytochrome C and downstream caspase-3 activation. | Simvastatin | caspase 3 | Homo sapiens |