Title : Molecular determinants of response to 5-fluorouracil-based chemotherapy in colorectal cancer: The undisputable role of micro-ribonucleic acids.

Pub. Date : 2020 Sep 15

PMID : 33005290






1 Functional Relationships(s)
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1 Different mechanisms including microsatellite instability, increased expression level of key enzyme thymidylate synthase and its polymorphism, increased level of 5-FU-activating enzymes and mutation of TP53 are proposed as the main determinants of resistance to 5-FU in CRC cells. Fluorouracil tumor protein p53 Homo sapiens