Title : Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity.

Pub. Date : 2020 Oct 22

PMID : 33001648






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site. Arginine angiotensin converting enzyme 2 Homo sapiens
2 Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site. Arginine angiotensin converting enzyme 2 Homo sapiens
3 Angiotensin-converting enzyme 2 (ACE-2), neprilysin (NEP), and plasma kallikrein (KLKB1) cleave and inactivate it, with the latter cutting within the arginine-arginine site. Arginine angiotensin converting enzyme 2 Homo sapiens