Pub. Date : 2020 Nov
PMID : 33000210
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of tacrolimus on the TGF-beta1/SMAD signaling pathway in paraquat-exposed rat alveolar type II epithelial cells. | Tacrolimus | transforming growth factor, beta 1 | Rattus norvegicus |
| 2 | The expression levels of TGF-beta1, SMAD3 and CTGF, as well as their concentrations in the culture supernatant, were significantly downregulated in the tacrolimus group compared with the paraquat group. | Tacrolimus | transforming growth factor, beta 1 | Rattus norvegicus |
| 3 | In conclusion, tacrolimus can reduce the levels of TGF-beta1, SMAD3 and CTGF, increase the level of SMAD7 in TGF-beta1 signaling pathway and protect the development of pulmonary fibrosis in paraquat exposed alveolar epithelial cells. | Tacrolimus | transforming growth factor, beta 1 | Rattus norvegicus |
| 4 | In conclusion, tacrolimus can reduce the levels of TGF-beta1, SMAD3 and CTGF, increase the level of SMAD7 in TGF-beta1 signaling pathway and protect the development of pulmonary fibrosis in paraquat exposed alveolar epithelial cells. | Tacrolimus | transforming growth factor, beta 1 | Rattus norvegicus |