Pub. Date : 2021 Jan
PMID : 32994182
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we investigated whether metformin mitigates breast cancer metastasis induced by a DPP-4 inhibitor via suppression of mTOR signaling. | Metformin | dipeptidyl peptidase 4 | Homo sapiens |
| 2 | In cultured mouse mammary and human breast cancer cells, metformin suppressed DPP-4 inhibitor KR62436 (KR)-induced EMT and cell migration via suppression of the mTOR pathway associated with AMPK activation. | Metformin | dipeptidyl peptidase 4 | Homo sapiens |
| 3 | Our findings suggest that metformin may serve as an antimetastatic agent by mitigating the undesirable effects of DPP-4 inhibitors in patients with certain cancers. | Metformin | dipeptidyl peptidase 4 | Homo sapiens |
| 4 | Implications: Metformin could combat the detrimental effects of DPP-4 inhibitor on breast cancer metastasis via mTOR suppression, suggesting the potential clinical relevance. | Metformin | dipeptidyl peptidase 4 | Homo sapiens |