Title : Solvent Deuterium Oxide Isotope Effects on the Reactions of Organophosphorylated Acetylcholinesterase.

Pub. Date : 2020 Sep 25

PMID : 32992925






1 Functional Relationships(s)
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1 Organophosphates (OPs) are esters of substituted phosphates, phosphonates or phosphoramidates that react with acetylcholinesterase (AChE) by initially transferring the organophosphityl group to a serine residue in the enzyme active site, concomitant with loss of an alcohol or halide leaving group. phosphoramidic acid acetylcholinesterase (Cartwright blood group) Homo sapiens