Title : Action of 1,25(OH)2D3 on Human Asthmatic Bronchial Fibroblasts: Implications for Airway Remodeling in Asthma.

Pub. Date : 2020

PMID : 32982316






2 Functional Relationships(s)
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1 Our aim was to investigate the anti-fibrogenic effect of 1,25(OH)2D3 in TGF-beta1 or TNF-alpha-IL-1beta-stimulated human bronchial fibroblast cells (HBFCs) from severe asthmatic compared with non-asthmatic subjects. Calcitriol tumor necrosis factor Homo sapiens
2 Additionally, we observed decreased mRNA expression of FN 1, LUM, BGN, MMP2, COL5A1, TIMP1 and CC-chemokines (CCL2, CCL5, CCL11) in response to 1,25(OH)2D3 addition to the TGF-beta1 or TNF-alpha-IL-1beta-stimulated HBFCs. Calcitriol tumor necrosis factor Homo sapiens