Title : Interaction of Halogenated Tyrosine/Phenylalanine Derivatives with Organic Anion Transporter 1 in the Renal Handling of Tumor Imaging Probes.

Pub. Date : 2020 Dec

PMID : 32981893






1 Functional Relationships(s)
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1 In structure-activity relationship analyses, removal of either the 3-halogen or 4-hydroxyl group from FAMT or its structural analog 3-iodo-alpha-methyl-l-tyrosine greatly decreased the interaction with OAT1, reducing the [14C]p-aminohippurate uptake inhibition and the efflux induction. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens