Title : The bromodomain and extra-terminal domain inhibitor JQ1 synergistically sensitizes human colorectal cancer cells to topoisomerase I inhibitors through repression of Mre11-mediated DNA repair pathway.

Pub. Date : 2021 Apr

PMID : 32981006






1 Functional Relationships(s)
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1 Camptothecin (CPT) and its derivatives, irinotecan and topotecan are specific topoisomerase I (Top1) inhibitors and potent anticancer drugs. Topotecan DNA topoisomerase I Homo sapiens