Title : Exploding the Repeat Length Paradigm while Exploring Amyloid Toxicity in Huntington's Disease.

Pub. Date : 2020 Oct 20

PMID : 32975927






1 Functional Relationships(s)
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1 In both models, novel htt-ex1-betaHP analogues exhibiting strong aggregation in spite of their very short polyQ repeat lengths proved to be toxic, dramatically breaking the "repeat length paradigm" and strongly suggesting that the toxic species must be some kind of aggregate. polyglutamine huntingtin Drosophila melanogaster