Title : Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron.

Pub. Date : 2020 Sep 23

PMID : 32968051






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Hemin caused stabilization and nuclear translocation of Nrf2, which induced heme oxygenase-1 (HO-1) and ferritin heavy chain (FtH). Hemin heme oxygenase 1 Homo sapiens
2 Hemin caused stabilization and nuclear translocation of Nrf2, which induced heme oxygenase-1 (HO-1) and ferritin heavy chain (FtH). Hemin heme oxygenase 1 Homo sapiens
3 Chemical inhibition or genetic knockdown of HO-1 potentiated hemin-triggered ROS generation and oxidative DNA damage preferentially in HCEC. Hemin heme oxygenase 1 Homo sapiens
4 Furthermore, HO-1 abrogation strongly augmented the cytotoxic effects of hemin in HCEC, revealing its pivotal function in colonocytes and highlighting the toxicity of free intracellular heme iron. Hemin heme oxygenase 1 Homo sapiens
5 Importantly, HO-1 conferred protection against the detrimental effects of hemin. Hemin heme oxygenase 1 Homo sapiens