Title : Nicotine stimulates ion transport via metabotropic β4 subunit containing nicotinic ACh receptors.

Pub. Date : 2020 Dec

PMID : 32959891






3 Functional Relationships(s)
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1 KEY RESULTS: Apical application of the nAChR agonist nicotine transiently increased ISC (EC50 : 19.83 mumol*L-1 ). Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 The nicotine-effect was abolished by the nAChR inhibitor mecamylamine. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 CONCLUSIONS AND IMPLICATIONS: alpha3beta4 nAChR are responsible for the nicotine-induced current changes via Ca2+ -release from intracellular stores, PKA and ryanodine receptor activation. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus