Title : Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation.

Pub. Date : 2020 Sep 21

PMID : 32955441






2 Functional Relationships(s)
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1 Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation. polyglutamine Ribosomal protein S27A Drosophila melanogaster
2 We found that ataxin-3 pathogenicity is saliently controlled by polyglutamine-adjacent ubiquitin-interacting motifs (UIMs) that enhance aggregation and toxicity. polyglutamine Ribosomal protein S27A Drosophila melanogaster