Pub. Date : 2020 Sep 11
PMID : 32953930
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Because Smad7 functions as an inhibitor for both TGF-beta/Smad and nuclear factor kappaB (NF-kappaB) signaling, increased cardiac Smad7 could be another mechanism through which SIS3 treatment blocked Smad3-mediated myocardial fibrosis and NF-kappaB-driven cardiac inflammation. | 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride | SMAD family member 7 | Mus musculus |
| 2 | Because Smad7 functions as an inhibitor for both TGF-beta/Smad and nuclear factor kappaB (NF-kappaB) signaling, increased cardiac Smad7 could be another mechanism through which SIS3 treatment blocked Smad3-mediated myocardial fibrosis and NF-kappaB-driven cardiac inflammation. | 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride | SMAD family member 7 | Mus musculus |
| 3 | Because Smad7 functions as an inhibitor for both TGF-beta/Smad and nuclear factor kappaB (NF-kappaB) signaling, increased cardiac Smad7 could be another mechanism through which SIS3 treatment blocked Smad3-mediated myocardial fibrosis and NF-kappaB-driven cardiac inflammation. | 6,7-dimethyl-2-(2E)-3-(1-methyl-2-phenyl-1H-pyrrolo(2,3-b)pyridin-3-yl-prop-2-enoyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride | SMAD family member 7 | Mus musculus |