Title : Non-cytotoxic doses of shikonin inhibit lipopolysaccharide-induced TNF-α expression via activation of the AMP-activated protein kinase signaling pathway.

Pub. Date : 2020 Nov

PMID : 32952636






1 Functional Relationships(s)
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1 The present results suggested that the non-cytotoxic doses of shikonin effectively inhibited lipopolysaccharide (LPS)-induced reactive oxygen species production, NF-kappaB activation and TNF-alpha expression in RAW 264.7 mouse macrophages via AMP-activated protein kinase (AMPK) signaling pathway. shikonin nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus