Pub. Date : 1988 Aug
PMID : 3293991
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | One is the demonstration that cellular 90K hsp (hsp-90) can complex with steroid receptors in vitro and inhibit their ability to interact with DNA, and second, the demonstration that in avian oviduct sex steroids can regulate the synthesis of hsp-108. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 2 | As yet, there is no report that sex steroids can regulate hsp-90 synthesis, especially in mammalian tissues. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 3 | We report that ovariectomy reduces the uterine concentration of hsp-90, and estradiol causes a time-dependent increase in uterine hsp-90 as early as 4 h after steroid administration, reaching a maximum increase of 4-fold between 18-24 h. The effect is specific to estrogens and not elicited by other steroid hormones. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |
| 4 | We report that ovariectomy reduces the uterine concentration of hsp-90, and estradiol causes a time-dependent increase in uterine hsp-90 as early as 4 h after steroid administration, reaching a maximum increase of 4-fold between 18-24 h. The effect is specific to estrogens and not elicited by other steroid hormones. | Steroids | heat shock protein 90 alpha family class A member 1 | Homo sapiens |