Title : Translational pharmacology of an inhaled small molecule αvβ6 integrin inhibitor for idiopathic pulmonary fibrosis.

Pub. Date : 2020 Sep 16

PMID : 32938936






1 Functional Relationships(s)
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1 In the murine bleomycin-induced lung fibrosis model, GSK3008348 engages alphavbeta6, induces prolonged inhibition of TGFbeta signaling and reduces lung collagen deposition and serum C3M, a marker of IPF disease progression. Bleomycin transforming growth factor alpha Mus musculus