Pub. Date : 2020 Nov
PMID : 32934734
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Emodin alleviates gemcitabine resistance in pancreatic cancer by inhibiting MDR1/P-glycoprotein and MRPs expression. | Emodin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | In addition, emodin treatment reduced resistance to gemcitabine, which was characterized by the downregulation of P-glycoprotein, MRP1 and MRP5 expression in the group receiving combination treatment. | Emodin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | The level of P-glycoprotein was also decreased in the group treated with gemcitabine+emodin compared with the single treatment groups. | Emodin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Taken together, these results demonstrated that emodin enhanced gemcitabine efficacy in tumor treatment and alleviated gemcitabine resistance in PANC-1 cell xenografts in mice via suppressing MDR1/P-glycoprotein and MRP expression. | Emodin | ATP binding cassette subfamily B member 1 | Homo sapiens |