Pub. Date : 2020
PMID : 32903806
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer"s Disease. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 2 | Nicotinamide, a Poly [ADP-Ribose] Polymerase 1 (PARP-1) Inhibitor, as an Adjunctive Therapy for the Treatment of Alzheimer"s Disease. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 3 | Beyond its effect in NAD+ stores, nicotinamide is an inhibitor of Poly [ADP-ribose] polymerase 1 (PARP-1), an enzyme with multiple cellular functions, including regulation of cell death, energy/metabolism and inflammatory response. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 4 | Beyond its effect in NAD+ stores, nicotinamide is an inhibitor of Poly [ADP-ribose] polymerase 1 (PARP-1), an enzyme with multiple cellular functions, including regulation of cell death, energy/metabolism and inflammatory response. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 5 | Here we discuss the evidence supporting the use of nicotinamide as adjunctive therapy for the treatment of early stages of AD based on the inhibitory effect of nicotinamide on PARP-1 activity. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 6 | Here we discuss the evidence supporting the use of nicotinamide as adjunctive therapy for the treatment of early stages of AD based on the inhibitory effect of nicotinamide on PARP-1 activity. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |
| 7 | The data support evaluating nicotinamide as an adjunctive treatment for AD at early stages of the disease not only to increase NAD+ stores but as a PARP-1 inhibitor, raising the hypothesis that other PARP-1 inhibitors - drugs that are already approved for breast cancer treatment - might be explored for the treatment of AD. | Niacinamide | poly(ADP-ribose) polymerase 1 | Homo sapiens |