Title : Early processing of prothrombin and factor X by the vitamin K-dependent carboxylase.

Pub. Date : 1988 Jul 15

PMID : 3290218






2 Functional Relationships(s)
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1 In vitro 14CO2 gamma-carboxylation of these substrates, triggered by reduced vitamin K1H2, resulted in release of 14C-labeled prothrombin precursors from the membrane fragments, but no release of 14C-labeled factor X precursors could be demonstrated, which suggested a difference in early processing of these substrates by the carboxylase. 14co2 coagulation factor II Rattus norvegicus
2 On the other hand, the membrane concentration of prothrombin antigens did not increase in response to the drug, and 14CO2 gamma-carboxylation of the membrane pool of prothrombin carboxylase substrates was the same in warfarin and saline-treated rats. 14co2 coagulation factor II Rattus norvegicus