Pub. Date : 2020 Nov
PMID : 32901866
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Co-treatment with the TOPK inhibitor, OTS514, in combination with H2O2 increased p53 acetylation and its expression, whereas it decreased Sirtuin 1 (SIRT1) expression, contributing to the promotion of apoptosis. | Hydrogen Peroxide | tumor protein p53 | Homo sapiens |
| 2 | Furthermore, the p53 inhibitor, Pifithrin-mu, diminished the augmentation in poly(ADP-ribose) polymerase (PARP) cleavage induced by OTS514 plus H2O2, while the Mdm2 antagonist, Nutlin 3, increased PARP cleavage. | Hydrogen Peroxide | tumor protein p53 | Homo sapiens |
| 3 | Moreover, OTS514 further decreased the SIRT1 transcriptional activity decreased by H2O2, but promoted the H2O2-induced p53 or p21 transcriptional activity. | Hydrogen Peroxide | tumor protein p53 | Homo sapiens |
| 4 | Taken together, the findings of the present study demonstrate that TOPK inhibition promotes p53-mediated granulosa cell apoptosis through SIRT1 downregulation in response to H2O2. | Hydrogen Peroxide | tumor protein p53 | Homo sapiens |
| 5 | Therefore, it can be concluded that TOPK suppresses H2O2-induced apoptosis through the modulation of the p53/SIRT1 axis, suggesting a potential role of TOPK in the regulation of human granulosa cell apoptosis, leading to the promotion of abnormal follicular development. | Hydrogen Peroxide | tumor protein p53 | Homo sapiens |