Title : The Role of Thiocyanate in Modulating Myeloperoxidase Activity during Disease.

Pub. Date : 2020 Sep 3

PMID : 32899436






3 Functional Relationships(s)
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1 The Role of Thiocyanate in Modulating Myeloperoxidase Activity during Disease. thiocyanate myeloperoxidase Homo sapiens
2 Thiocyanate can outcompete chlorine anions and other halides (F-, Br-, I-) as substrates for myeloperoxidase by undergoing two-electron oxidation with hydrogen peroxide. thiocyanate myeloperoxidase Homo sapiens
3 As such, the pharmacological capacity of thiocyanate has been recently investigated for its ability to modulate myeloperoxidase activity for HOSCN, a less potent species relative to HOCl, although outcomes vary significantly across different disease models. thiocyanate myeloperoxidase Homo sapiens