Pub. Date : 2020 Oct
PMID : 32888708
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of ABCB1 3435C>T Genetic Polymorphism on Pharmacokinetic Variables of Tacrolimus in Adult Renal Transplant Recipients: a Systematic Review and Meta-analysis. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | PURPOSE: Tacrolimus is the substrate of multidrug-resistance 1 (ABCB1). | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | PURPOSE: Tacrolimus is the substrate of multidrug-resistance 1 (ABCB1). | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | However, the effect of ABCB1 C3435T polymorphism on pharmacokinetic variables of tacrolimus is controversial in different studies. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | This meta-analysis was conducted to explore the relationship between ABCB1 3435C>T genetic polymorphism and pharmacokinetic variables of tacrolimus. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | The study explored the relationship between ABCB1 3435C>T genetic polymorphism and pharmacokinetic variables of tacrolimus stratified according to time of posttransplantation, ethnicity, methods of concentration measurement, and the initial doses of tacrolimus. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | The subgroup analysis then revealed that the tacrolimus concentration/weight-adjusted daily dose ratio of ABCB1 3435T carriers was significantly higher than that of the ABCB1 3435CC group at 1 and 6 months. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 8 | Meanwhile, ABCB1 3435CT and TT both had a higher tacrolimus concentration/weight-adjusted daily dose ratio compared with ABCB1 3435CC. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 9 | IMPLICATIONS: Our meta-analysis identified that the ABCB1 3435C>T genetic polymorphism affected the pharmacokinetic variables of tacrolimus in adult renal transplant recipients. | Tacrolimus | ATP binding cassette subfamily B member 1 | Homo sapiens |