Title : Pioglitazone alleviates cisplatin nephrotoxicity by suppressing mitochondria-mediated apoptosis via SIRT1/p53 signalling.

Pub. Date : 2020 Oct

PMID : 32881246






2 Functional Relationships(s)
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1 Pioglitazone also reduced the activation of caspase-3 and caspase-9, lowered the ratio of Bax/Bcl-2, attenuated kidney pathological damage and dysfunction, down-regulated the expression of Acetyl-p53, PUMA-alpha and Bax and abated cell apoptosis after cisplatin treatment. Pioglitazone BCL2 associated X, apoptosis regulator Homo sapiens
2 Pioglitazone also reduced the activation of caspase-3 and caspase-9, lowered the ratio of Bax/Bcl-2, attenuated kidney pathological damage and dysfunction, down-regulated the expression of Acetyl-p53, PUMA-alpha and Bax and abated cell apoptosis after cisplatin treatment. Pioglitazone BCL2 associated X, apoptosis regulator Homo sapiens