Title : Activation of the executioner caspases-3 and -7 promotes microglial pyroptosis in models of multiple sclerosis.

Pub. Date : 2020 Aug 29

PMID : 32861242






2 Functional Relationships(s)
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1 Upon exposure to pyroptotic stimuli (ATP or nigericin), human microglia displayed caspase-3/7 activation and cleavage of caspase-3/7-specific substrates (e.g., DFF45, ROCK1, and PARP), with accompanying features of pyroptosis including GSDMD immunopositive pyroptotic bodies, IL-1beta release, and membrane rupture. Nigericin caspase 3 Homo sapiens
2 Upon exposure to pyroptotic stimuli (ATP or nigericin), human microglia displayed caspase-3/7 activation and cleavage of caspase-3/7-specific substrates (e.g., DFF45, ROCK1, and PARP), with accompanying features of pyroptosis including GSDMD immunopositive pyroptotic bodies, IL-1beta release, and membrane rupture. Nigericin caspase 3 Homo sapiens