Title : Intracellular adenosine released from THP-1 differentiated human macrophages is involved in an autocrine control of Leishmania parasitic burden, mediated by adenosine A2A and A2B receptors.

Pub. Date : 2020 Oct 15

PMID : 32858046






1 Functional Relationships(s)
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1 The tonic activation of adenosine A2 receptors was dependent on the release of intracellular adenosine through equilibrative nucleoside transporters (ENT1/ENT2): NBTI or dipyridamole reduced (~25%) whereas, when ENTs were blocked, adenosine A2 receptor antagonists failed to reduce and A2 agonists increase parasitic burden. 4-nitrobenzylthioinosine solute carrier family 29 member 1 (Augustine blood group) Homo sapiens