Pub. Date : 2020 Oct
PMID : 32856282
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In SARS-CoV-2 patients (n = 30), interleukin (IL)-6 and body surface area were covariates associated with darunavir oral clearance (CL/F) and volume of distribution (Vd), respectively; no covariates were identified in HIV patients (n = 25). | Darunavir | interleukin 6 | Homo sapiens |
| 2 | Increasing IL-6 levels affected darunavir concentration versus time simulated profiles. | Darunavir | interleukin 6 | Homo sapiens |
| 3 | We hypothesized that increases in IL-6 levels associated with severe SARS-CoV-2 disease may downregulate the cytochrome P450 (CYP) 3A4-mediated metabolism of darunavir. | Darunavir | interleukin 6 | Homo sapiens |