Pub. Date : 2021 Jan
PMID : 32852568
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The beneficial effects of reducing NLRP3 inflammasome activation in the cardiotoxicity and the anti-cancer effects of doxorubicin. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Recent studies have suggested that the Nucleotide-Binding Domain-Like Receptor Protein 3 (NLRP3) inflammasome is implicated in tumor progression and the chemoresistance of cancer cells to DOX. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Recent studies have suggested that the Nucleotide-Binding Domain-Like Receptor Protein 3 (NLRP3) inflammasome is implicated in tumor progression and the chemoresistance of cancer cells to DOX. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | Of interest, reducing NLRP3 inflammasome activity alleviates DOX-induced cardiotoxicity. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | Therefore, we postulate that strategies that target the NLRP3 inflammasome can help mitigate the cardiotoxic effects of DOX while maintaining and/or even enhancing its anti-cancer activity. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | Herein, we review the current knowledge about the potential implication of the NLRP3 inflammasome in the anti-cancer and cardiotoxic effects of DOX. | Doxorubicin | NLR family pyrin domain containing 3 | Homo sapiens |