Pub. Date : 2020 Sep 1
PMID : 32830148
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Delphinidin enhances radio-therapeutic effects via autophagy induction and JNK/MAPK pathway activation in non-small cell lung cancer. | delphinidin | mitogen-activated protein kinase 8 | Homo sapiens |
| 2 | Moreover, combined treatment with delphinidin and IR, enhanced apoptotic cell death, suppressed the mTOR pathway, and activated the JNK/MAPK pathway. | delphinidin | mitogen-activated protein kinase 8 | Homo sapiens |
| 3 | In addition, JNK phosphorylation was upregulated by delphinidin pre-treatment in radiation-exposed NSCLC cells. | delphinidin | mitogen-activated protein kinase 8 | Homo sapiens |
| 4 | Collectively, these results show that delphinidin acts as a radiation-sensitizing agent through autophagy induction and JNK/MAPK pathway activation, thus enhancing apoptotic cell death in NSCLC cells. | delphinidin | mitogen-activated protein kinase 8 | Homo sapiens |