Pub. Date : 2020 Nov 15
PMID : 32828944
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Raloxifene inhibits IL-6/STAT3 signaling pathway and protects against high-fat-induced atherosclerosis in ApoE-/- mice. | Raloxifene Hydrochloride | interleukin 6 | Mus musculus |
| 2 | Our previous studies found that Raloxifene targeted against IL-6/GP130 protein-protein interface and inhibited STAT3 phosphorylation induced by IL-6 in cancer cells. | Raloxifene Hydrochloride | interleukin 6 | Mus musculus |
| 3 | Our previous studies found that Raloxifene targeted against IL-6/GP130 protein-protein interface and inhibited STAT3 phosphorylation induced by IL-6 in cancer cells. | Raloxifene Hydrochloride | interleukin 6 | Mus musculus |
| 4 | However, whether Raloxifene could suppress IL-6/STAT3 signaling pathway and attenuate atherosclerosis in high-fat diet (HFD)-induced mice remains unknown. | Raloxifene Hydrochloride | interleukin 6 | Mus musculus |
| 5 | Histological analysis showed that the expression of IL-6, P-STAT3, ICAM-1, VCAM-1, CD68 and alpha-SMA were significantly decreased in the Raloxifene intervention group compared to HFD group. | Raloxifene Hydrochloride | interleukin 6 | Mus musculus |
| 6 | Moreover, we observed that IL-6 increased migration and cell viability of VSMCs and RAW264.7 cells, while Raloxifene treatment decreased migration and reduced cell viability of VSMCs and RAW264.7 cells stimulated by IL-6. | Raloxifene Hydrochloride | interleukin 6 | Mus musculus |
| 7 | SIGNIFICANCE: Raloxifene has effects on inhibiting atherosclerosis development, the underlying mechanisms might involve in inhibiting inflammation-related IL-6/STAT3 signaling pathway. | Raloxifene Hydrochloride | interleukin 6 | Mus musculus |