Pub. Date : 2020 Aug 19
PMID : 32825184
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As a follow-up study of our previous findings, here we have identified that the pharmacological substances, leptomycin B and doxorubicin, can improve the sensitivity of cervical cancer cells to cisplatin inducing HP1gamma-mediated elevation of p53. | Cisplatin | tumor protein p53 | Homo sapiens |
| 2 | Leptomycin B, which inhibits the nuclear export of HP1gamma, increased cisplatin-dependent apoptosis induction by promoting the activation of p53 signaling. | Cisplatin | tumor protein p53 | Homo sapiens |
| 3 | Doxorubicin sensitized the cisplatin-resistant cervical cancer cells, enhancing their p53 levels and rate of apoptosis when administered together with cisplatin. | Cisplatin | tumor protein p53 | Homo sapiens |
| 4 | Our findings reveal a therapeutic strategy to target a specific molecular pathway that contributes to p53 degradation for the treatment of patients with cervical cancer, particularly with cisplatin resistance. | Cisplatin | tumor protein p53 | Homo sapiens |