Title : Lead Finding from Selected Flavonoids with Antiviral (SARS-CoV-2) Potentials Against COVID-19: An In-silico Evaluation.

Pub. Date : 2021

PMID : 32819226






4 Functional Relationships(s)
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1 OBJECTIVE: In this aspect, our objective was to screen essential flavonoids against possible protein targets such as SARS-CoV-2 spike glycoprotein receptor binding domain (RBD-S) and host Angiotensin Converting Enzyme-2 protease domain (PD-ACE-2) using in silico molecular docking studies. Flavonoids angiotensin converting enzyme 2 Homo sapiens
2 OBJECTIVE: In this aspect, our objective was to screen essential flavonoids against possible protein targets such as SARS-CoV-2 spike glycoprotein receptor binding domain (RBD-S) and host Angiotensin Converting Enzyme-2 protease domain (PD-ACE-2) using in silico molecular docking studies. Flavonoids angiotensin converting enzyme 2 Homo sapiens
3 The flavonoids that passed Lipinski rule were subjected to in silico analysis through molecular docking on RBD-S and PD-ACE-2 using Molegro Virtual Docker v6.0. Flavonoids angiotensin converting enzyme 2 Homo sapiens
4 CONCLUSION: The current outcomes created a new paradigm in understanding biochanin A and silymarin bioflavonoids as potent inhibitors of RBD-Sand PD-ACE-2 targets respectively, further work can be extended to confirm their therapeutic potential in COVID-19. Flavonoids angiotensin converting enzyme 2 Homo sapiens