Title : Aconitase 2 sensitizes MCF-7 cells to cisplatin eliciting p53-mediated apoptosis in a ROS-dependent manner.

Pub. Date : 2020 Oct

PMID : 32818504






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Aconitase 2 sensitizes MCF-7 cells to cisplatin eliciting p53-mediated apoptosis in a ROS-dependent manner. Cisplatin tumor protein p53 Homo sapiens
2 This response was driven by the accumulation of reactive oxygen species (ROS) following both ACO2 overexpression and CDDP exposure that permit the stabilization/activation of p53 in nuclear and mitochondrial compartments. Cisplatin tumor protein p53 Homo sapiens