Pub. Date : 2020 Dec
PMID : 32811220
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-alpha secretion from M1 macrophages. | Capsaicin | tumor necrosis factor | Mus musculus |
| 2 | Capsaicin inhibited M1 polarization of macrophage by regulating Notch signaling leading to the reduced secretion of inflammatory cytokine TNF-alpha that correspondingly attenuates myofibroblasts regeneration and fibrosis formation of hepatocyte stellate cells (HSCs). | Capsaicin | tumor necrosis factor | Mus musculus |
| 3 | CONCLUSION: Taken together, capsaicin alleviates liver fibrosis by inactivation of Notch signaling and further inhibiting TNF-alpha secretion from M1 macrophage. | Capsaicin | tumor necrosis factor | Mus musculus |