Title : MDM2 Antagonists Induce a Paradoxical Activation of Erk1/2 through a P53-Dependent Mechanism in Dedifferentiated Liposarcomas: Implications for Combinatorial Strategies.

Pub. Date : 2020 Aug 12

PMID : 32806555






1 Functional Relationships(s)
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1 The upregulation of p-ERK occurred due to mitochondrial translocation of p53, which resulted in increased production of reactive oxygen species, causing the activation of receptor tyrosine kinases (RTKs). Oxygen tumor protein p53 Homo sapiens