Title : Discovery of Evodiamine Derivatives as Highly Selective PDE5 Inhibitors Targeting a Unique Allosteric Pocket.

Pub. Date : 2020 Sep 10

PMID : 32794708






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 This movement directly blocks the binding of substrate/inhibitors to the PDE5 active site, which is different from all traditional PDE5 inhibitors such as sildenafil, tadalafil, and vardenafil. Sildenafil Citrate phosphodiesterase 5A Homo sapiens
2 This movement directly blocks the binding of substrate/inhibitors to the PDE5 active site, which is different from all traditional PDE5 inhibitors such as sildenafil, tadalafil, and vardenafil. Sildenafil Citrate phosphodiesterase 5A Homo sapiens