Title : Cancer-associated fibroblasts promote the migration and invasion of gastric cancer cells via activating IL-17a/JAK2/STAT3 signaling.

Pub. Date : 2020 Jul

PMID : 32793721






3 Functional Relationships(s)
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Protein Name
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1 IL-17a was blocked with a polyclonal antibody, and JAK2/STAT3 signaling pathway was blocked by a specific inhibitor AG490. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide Janus kinase 2 Homo sapiens
2 IL-17a neutralizing antibody or JAK2 inhibitor AG490 can significantly inhibit the effects of CAFs on the migration, invasion, MMP2/9, TIMP1/2, and JAK2/STAT3 pathways of GC cells. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide Janus kinase 2 Homo sapiens
3 IL-17a neutralizing antibody or JAK2 inhibitor AG490 can significantly inhibit the effects of CAFs on the migration, invasion, MMP2/9, TIMP1/2, and JAK2/STAT3 pathways of GC cells. alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide Janus kinase 2 Homo sapiens