Title : NRF2/ACSS2 axis mediates the metabolic effect of alcohol drinking on esophageal squamous cell carcinoma.

Pub. Date : 2020 Aug 28

PMID : 32776152






3 Functional Relationships(s)
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1 In this study, hyperactive NRF2 was found to upregulate acetyl-CoA synthetase short-chain family members 2 (ACSS2), an enzyme that converts acetate to acetyl-CoA, in ESCC cells and mouse esophagus. Acetyl Coenzyme A acyl-CoA synthetase short-chain family member 2 Mus musculus
2 We also showed that knockdown of NRF2 or ACSS2 led to decreased ACSS2 expression, which in turn reduced the levels of acetyl-CoA and ATP with or without ethanol exposure. Acetyl Coenzyme A acyl-CoA synthetase short-chain family member 2 Mus musculus
3 We also showed that knockdown of NRF2 or ACSS2 led to decreased ACSS2 expression, which in turn reduced the levels of acetyl-CoA and ATP with or without ethanol exposure. Acetyl Coenzyme A acyl-CoA synthetase short-chain family member 2 Mus musculus