Title : S100B protein: general characteristics and pathophysiological implications in the Central Nervous System.

Pub. Date : 2022 Mar

PMID : 32772615






3 Functional Relationships(s)
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1 Background: Calcium-binding proteins are heterogeneous proteins that act binding this ion in specific domains, performing numerous functions.Objective: In the present review, we aim to gather principal information about S100B protein in the Central Nervous System (CNS), highlighting its particularities, mapping, functionalities, and consequences on CNS dysfunction.Methods: The research was carried out by searching Pubmed, Medline, Science Direct, Lilacs, the Cochrane Library, and Web of Science databases using the following descriptors: S100 protein; Central Nervous System; Nervous Lesions, as well as their corresponding terms in Portuguese and Spanish. Calcium S100 calcium binding protein B Homo sapiens
2 Background: Calcium-binding proteins are heterogeneous proteins that act binding this ion in specific domains, performing numerous functions.Objective: In the present review, we aim to gather principal information about S100B protein in the Central Nervous System (CNS), highlighting its particularities, mapping, functionalities, and consequences on CNS dysfunction.Methods: The research was carried out by searching Pubmed, Medline, Science Direct, Lilacs, the Cochrane Library, and Web of Science databases using the following descriptors: S100 protein; Central Nervous System; Nervous Lesions, as well as their corresponding terms in Portuguese and Spanish. Calcium S100 calcium binding protein B Homo sapiens
3 The terms were first searched separately, then together.Results: Due to its ability to bind with calcium, S100B is involved in the regulation of several intra- and extracellular physiological processes. Calcium S100 calcium binding protein B Homo sapiens