Pub. Date : 2020
PMID : 32767949
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A Ferrocene Derivative Reduces Cisplatin Resistance in Breast Cancer Cells Through Suppression of MDR-1 Expression and Modulation of JAK2/STAT3 Signaling Pathway. | Cisplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | RESULTS: Overexpression of MDR1 as well as a markedly increase in the level of phosphorylated STAT3 was observed in cisplatin-resistant MCF-7 (MCF-7R) cells. | Cisplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | FMSP successfully reduced the MCF-7R cell viability and reversed both MDR1 expression and STAT3 phosphorylation status through which sensitivity of MCF-7R cells to cisplatin treatment was regained. | Cisplatin | ATP binding cassette subfamily B member 1 | Homo sapiens |