Pub. Date : 2020 Nov
PMID : 32761352
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The beta-carboline harmine, which induces hypothermia and tremor, is metabolized by CYP2D6 to the non-hypothermic/non-tremorgenic harmol. | norharman | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |
| 2 | These findings suggest that human CYP2D6 in the brain is protective against beta-carboline-induced neurotoxicity and that the extensive interindividual variability in CYP2D6 expression in human brain may contribute to variation in susceptibility to certain neurotoxin-associated neurodegenerative disorders. | norharman | cytochrome P450 family 2 subfamily D member 6 | Homo sapiens |